Drug Interactions With Glipizide and Metformin

If certain medications are combined, there is a potential for drug interactions. With glipizide and metformin, these interactions can make the drug less effective, potentially increasing your risk of side effects or increasing your chance of high blood sugar. Medications that can cause interactions include decongestants, diuretics, and oral contraceptives. If drug interactions with glipizide and metformin are a concern, your healthcare provider may adjust your dosage.

 

An Overview of Drug Interactions With Glipizide and Metformin

Glipizide and metformin (Metaglip®) can potentially interact with several medications. Some of the medicines that can lead to drug interactions with glipizide and metformin include:
 
  • Beta blockers, such as:
 
 
 
 
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Cimetidine (Tagamet®)
     
  • Corticosteroids, such as:
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®).
 
  • Diuretics, such as:
 
 
  • Estrogens
     
  • Isoniazid
     
  • Monoamine oxidase inhibitors (MAOIs), including:
 
 
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Phenytoin (Dilantin®)
     
  • Probenecid (Benuryl®, ColBenemid®)
     
  • Salicylates, such as:
 
    • Aspirin
    • Choline magnesium trisalicylate (Trilisate®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®).
 
  • Sulfonamides ("sulfa drugs"), including:
 
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®).
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Glipizide and Metformin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;