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Drug Interactions With Glipizide and Metformin

Phenytoin
If glipizide and metformin is combined with phenytoin, this can make glipizide and metformin less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide and metformin dose, especially when starting or stopping phenytoin, depending on your particular situation.
 
Probenecid
Taking glipizide and metformin with probenecid can increase your risk of low blood sugar (hypoglycemia). As a result, you may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide and metformin dose, especially when starting or stopping probenecid.
 
Salicylates
Combining glipizide and metformin with salicylates can increase your risk of low blood sugar (hypoglycemia). To prevent this interaction, you may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide and metformin dose, especially when starting or stopping a salicylate.
 
Sulfonamides
If glipizide and metformin is taken with sulfonamides, this can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide and metformin dose, especially when starting or stopping a sulfonamide, to prevent this.
 
Warfarin
Taking glipizide and metformin with warfarin can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide and metformin dose, especially when starting or stopping warfarin.
 

Final Thoughts on Drug Interactions With Glipizide and Metformin

It is possible that not all drug interactions with glipizide and metformin were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
Healthy Eating for People With Diabetes

Glipizide and Metformin Information

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