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Drug Interactions With Glipizide and Metformin

More Information on Interactions With Glipizide and Metformin

The following sections explain in detail the potentially negative interactions that can occur when glipizide and metformin is combined with any of the drugs listed above.
 
Beta Blockers
Taking glipizide and metformin with beta blockers can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide and metformin dose, especially when starting or stopping a beta blocker.
 
Calcium Channel Blockers
If glipizide and metformin is combined with calcium channel blockers, this can make glipizide and metformin less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glipizide and metformin dose, especially when starting or stopping a calcium channel blocker, to prevent this interaction from occurring.
 
Certain Decongestants
If glipizide and metformin is taken with certain decongestants, this can make glipizide and metformin less effective, which may increase your chance of high blood sugar (hyperglycemia). Decongestants are in many cough and cold products, so talk to your healthcare provider before taking any of these.
 
Cimetidine
Combining glipizide and metformin with cimetidine can increase the level of glipizide and metformin in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to adjust your dose of these medications or may suggest an alternative to cimetidine, depending on your particular situation.
 
Colesevelam
Colesevelam interferes with the absorption of glipizide into the body, perhaps making it less effective. To avoid this interaction, be sure to take glipizide and metformin at least four hours before colesevelam.
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Glipizide and Metformin Information

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