Glimepiride (Amaryl^®) is a prescription medication that has been approved to treat type 2 diabetes. Glimepiride works by lowering blood sugar levels, which can decrease the risks of developing long-term problems associated with diabetes, including heart disease, diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. The dosage of glimepiride your healthcare provider prescribes will depend on several factors, including your age, other medical conditions you may have, and other medications you are taking. There are some possible side effects of glimepiride, such as nausea, headaches, and dizziness.