Is Depression a Glimepiride Side Effect?

There are several possible side effects for people taking glimepiride (Amaryl^®). Depression, however, does not appear to be one of them. In clinical studies, depression was not reported as either a common or rare side effect of glimepiride.

 

Keep in mind that just because depression was not seen during clinical studies, it does not mean that the medicine is not causing this problem for you. Clinical trials are designed to factor out as many variables as possible in order to understand whether the medicine works and what its possible side effects are. Once the medicine is approved, a wider range of people begin taking the medicine and for longer periods of time. As is often the case, this can lead to other side effects being reported. However, once a medicine is approved, a drug does not usually continue to be studied. This means that certain side effects that occur very rarely may never be reported. So, for an individual person, it is difficult to say with complete assurance that a particular complaint is not due to a medicine, even if the complaint is not a reported side effect.