Drug Interactions With Glimepiride

As with any medication, there are potential drug interactions with glimepiride. Taking glimepiride with other medications, such as certain decongestants, some antifungal medications, and beta blockers, can increase your risk of low blood sugar or increase the level of glimepiride in your blood. As a result, some of these drug interactions can potentially increase your risk of side effects.

 

An Overview of Glimepiride Drug Interactions

Glimepiride (Amaryl®) can potentially interact with many drugs. Some of the drugs that may lead to glimepiride interactions include:
 
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®)
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
  • Estrogens
     
  • Isoniazid
     
  • Monoamine oxidase inhibitors (MAOIs), including
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Ibuprofen (Motrin®, Advil®)
o Diclofenac (Cataflam®, Voltaren®)
o Ketoprofen (Orudis®)
o Promethazine (Phenergan®)
  • Rifampin (Rifadin®) or rifapentine (Priftin®)
     
  • Salicylates, such as aspirin, choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®)
     
  • Sulfonamides ("sulfa drugs"), including sulfadiazine, sulfadoxine (Fansidar®), sulfamethoxazole (Bactrim®, Septra®), and sulfisoxazole (Gantrisin®)
     
  • Thyroid medications, such as levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Unithroid®), liothyronine (Cytomel®), thyroid (Armour Thyroid®), and Thyrolar®
     
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Glimepiride Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;