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Drug Interactions With Glimepiride

Estrogens
Taking glimepiride with estrogens can make glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping an estrogen.
 
Fluoxetine
Taking glimepiride with fluoxetine can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dosage, especially when starting or stopping fluoxetine.
 
Fluoroquinolones
Taking glimepiride with a fluoroquinolone can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dosage, especially when starting or stopping a fluoroquinolone.
 
Isoniazid
Taking glimepiride with isoniazid can make glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping isoniazid.
 
Monoamine Oxidase inhibitors (MAOIs)
Taking glimepiride with monoamine oxidase inhibitors can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping an MAOI.
 
Niacin
Taking glimepiride with niacin can make glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping niacin.
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