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Drug Interactions With Glimepiride

Glimepiride Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when glimepiride is combined with any of the drugs listed above.
 
Beta Blockers
Taking glimepiride with beta blockers can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping a beta blocker.
 
Certain Antifungals
Taking glimepiride with certain antifungals can increase the level of glimepiride in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and/or adjust your dose of these medications.
 
Certain Decongestants
Taking glimepiride with certain decongestants can make glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping decongestants.
 
Certain Seizure Medications
Taking glimepiride with certain seizure medications can make glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping phenytoin.
 
Chloramphenicol (Chloromycetin)
Taking glimepiride with chloramphenicol can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping chloramphenicol.
 
Clarithromycin
Taking glimepiride with clarithromycin can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping clarithromycin. In some cases, a different antibiotic may be preferred.
 
Colesevelam
Colesevelam interferes with the absorption of glimepiride into the body, perhaps making it less effective. To avoid this interaction, be sure to take glimepiride at least four hours before colesevelam.
  
Corticosteroids
Taking glimepiride with corticosteroids can make glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping a corticosteroid.
 
Disopyramide
Taking glimepiride with disopyramide can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dosage, especially when starting or stopping disopyramide.
  
Diuretics
Taking glimepiride with diuretics can make glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your glimepiride dose, especially when starting or stopping a diuretic.
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