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Drug Interactions With Extended-Release Exenatide

There is a theoretical possibility that extended-release exenatide may interfere with certain other drugs. Interactions with extended-release exenatide may occur when this medicine is combined with Byetta, insulin, or certain other diabetes medications. Some of these reactions may result in dangerously low blood sugar levels or a decreased effectiveness of the medications.

An Overview of Extended-Release Exenatide Interactions

Extended-release exenatide (Bydureon™) may interact with other drugs, at least theoretically. It may decrease the absorption of other medications, and some medications may increase the risk of low blood sugar levels in people using extended-release exenatide.
Also, extended-release exenatide and Byetta® contain the same active ingredient; Byetta contains a short-acting version of exenatide, while extended-release exenatide contains a long-acting version. Therefore, they should never be combined.

Extended-Release Exenatide and Drug Absorption

Extended-release exenatide is a prescription diabetes medication that partially works by slowing down the movement of food through the stomach. This action can be helpful for controlling blood sugar levels. However, this could possibly decrease the absorption of other medications, as most medications are more effectively absorbed from the small intestine rather than the stomach. In most cases, this is likely not a problem. However, this interaction could be a problem for any drug that is quite sensitive to small changes.
However, such interactions are still largely theoretical in nature, and studies have not shown that extended-release exenatide decreases the absorption of other drugs to any clinically significant degree. As a good example, theoretically, extended-release exenatide could decrease the absorption of warfarin (Coumadin®, Jantoven®, an anticoagulant "blood thinner" medication), perhaps making it less effective. However, studies have not shown this to be the case. In fact, there have even been a few reports that exenatide (the active ingredient in extended-release exenatide) might even increase the action of warfarin.
To minimize any risks, talk with your healthcare provider or pharmacist about possible drug interactions that may apply to you before starting extended-release exenatide. He or she can review your other medications to see if any of them may be particularly sensitive to any small changes. If you happen to be taking such medications, you may need to be monitored a little more frequently than usual.
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Extended-Release Exenatide Information

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