Drug Interactions With Exenatide

As with any medication, there are potential drug interactions with exenatide. Taking exenatide with other medications, such as antibiotics, oral contraceptives, and Tylenol, can lead to problems. Some of these interactions can make the medications less effective because exenatide can slow the movement of the medications through the digestive tract. Therefore, be sure to talk to your healthcare provider about any potential drug interactions with exenatide that may apply to you.

An Overview of Drug Interactions With Exenatide

Exenatide (Byetta®) can potentially interact with a few medicines. Some of the medicines that may lead to exenatide interactions include:
 
(Click Byetta and Alcohol for information about the possible interaction between alcohol and exenatide.)
 

Exenatide Interactions Explained

Acetaminophen (Tylenol)
Taking acetaminophen after taking exenatide can decrease the amount of acetaminophen absorbed into your blood, perhaps making it less effective. This interaction does not seem to occur if acetaminophen is taken before a exenatide injection.
 
Antibiotics
Exenatide can slow the movement of medications through the digestive tract, and this may make some antibiotics less effective. To avoid this problem, take your doses of antibiotics at least one hour before an exenatide injection. If you must take your antibiotic with food, take it with a snack.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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