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Canagliflozin Side Effects

Common Side Effects

Canagliflozin has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking canagliflozin were documented and compared to the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients). As a result, it is possible to see what side effects occurred, how often they appeared, and how they compared to the group taking the placebo.
 
In these studies, the most common side effects of canagliflozin included:
 
  • Genital fungal infections in women (mostly yeast infections) -- in up to 11.4 percent of people
  • Urinary tract infections (such as a bladder infection) -- up to 5.9 percent
  • Increased urination -- up to 5.3 percent
  • Genital fungal infections in men (mostly infections of the penis in uncircumcised men) -- up to 4.2 percent
  • Low blood sugar (hypoglycemia) -- up to 3.6 percent
  • Low blood pressure, dizziness, fainting, or dehydration -- up to 3.6 percent
  • Vaginal itching -- up to 3 percent
  • Thirst -- up to 2.8 percent
  • Constipation -- up to 2.3 percent
  • Nausea -- up to 2.3 percent.
 
Canagliflozin typically causes a small decrease in kidney function (as estimated by blood tests). However, episodes of more severe decreases in kidney function (defined as a drop of 30 percent or more) occurred in up to 4.1 percent of people with normal or slightly impaired kidney function and up to 22.5 percent of people with moderate kidney impairment.
 
Canagliflozin also has a tendency to lower blood pressure by 3.7 to 5.4 mmHg, on average, and to increase LDL cholesterol ("bad cholesterol") by 4.5 to 8 percent, on average.
 
Weight loss is another possible side effect of canagliflozin. In studies, people taking canagliflozin lost an average of 2.8 to 3.9 kg (about 6 to 9 lbs), depending on the dosage, over a period of 26 weeks, compared to a smaller weight loss of slightly more than 1 lb in people taking a placebo.
 
7 Signs of High Blood Sugar

Canagliflozin Drug Information

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