You should talk with your healthcare provider prior to taking canagliflozin if you have:
- Kidney disease, such as kidney failure (renal failure)
- Low blood pressure (hypotension)
- High blood potassium levels (hyperkalemia)
- Problems with yeast infections
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- An uncircumcised male
- Pregnant or thinking of becoming pregnant (see Invokana and Pregnancy)
- Breastfeeding (see Invokana and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Canagliflozin to learn more, including information on who should not take the drug.)
As mentioned earlier, canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. Normally, the kidneys filter glucose (sugar) out of the blood and into the urine. However, SGLT transporters help this glucose to be reabsorbed back into the blood in the kidneys. Essentially, the kidneys filter out and then "reclaim" the glucose.
Canagliflozin inhibits one of the types of these transporters, preventing the kidneys from reabsorbing the glucose. This leads to glucose loss through the urine.