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What Is Alogliptin Used For?

How Does This Medicine Work?

Alogliptin belongs to a group of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones in the body. These hormones cause insulin to be released from the pancreas (which lowers blood glucose levels) in response to meals. They also reduce the amount of glucagon released by the pancreas, which reduces glucose (sugar) production by the liver.
 
By blocking the DPP-4 enzyme, alogliptin slows the breakdown of incretin hormones, increasing the level of these hormones in the blood. It is this increase in incretin hormones that is responsible for the beneficial actions of alogliptin, including increasing insulin production in response to meals and decreasing the amount of glucose that the liver produces. These effects work in combination to lower blood sugar levels.
 

Can Children Use It?

Alogliptin has not been adequately studied in children, and is not approved for use in this age group (usually defined as individuals younger than 18 years old). Talk to your child's healthcare provider about the risks and benefits of using this drug in children.
 

Is It Safe for Older Adults to Use Alogliptin?

Alogliptin can be used in older adults. In clinical studies, older adults did not appear to respond to the medication any differently than younger age groups.
 
However, only 4 percent of people in alogliptin clinical trials were over the age of 75. It is possible that some older adults may be more sensitive to the effects of this medication. In general, older adults may need more careful monitoring during alogliptin treatment. 
 

What About Off-Label Uses?

On occasion, a healthcare provider may recommend this medication for treating something other than type 2 diabetes in adults. This is called an "off-label" use. At this time, there are no well-accepted off-label uses for alogliptin.
 
Common Symptoms of Diabetic Neuropathy

Alogliptin Drug Information

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