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What Is Alogliptin and Pioglitazone Used For?

How Does This Medicine Work?

As mentioned already, this drug contains alogliptin and pioglitazone, which work in different ways to control blood sugar.
Alogliptin belongs to a group of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down certain hormones known as incretin hormones. These hormones cause insulin to be released from the pancreas (which lowers blood glucose levels) in response to meals. They also reduce the amount of glucagon released by the pancreas, which reduces glucose (sugar) production by the liver.
By blocking the DPP-4 enzyme, alogliptin and pioglitazone increases the level of incretin hormones in the blood. This causes more insulin to be made in response to meals and reduces the amount of glucose made by the liver.
Pioglitazone belongs to a group of medicines known as thiazolidinediones, or simply "glitazones." Glitazones work by improving insulin sensitivity in muscle and fat. This means it helps the cells respond better to insulin, which lowers blood sugar. It also reduces the amount of glucose released by the liver.

Can Children Use It?

Alogliptin and pioglitazone has not been adequately studied in children, and is not approved for use in this age group (usually defined as individuals younger than age 18). Talk to your child's healthcare provider about the risks and benefits of using this medication in children.

Is It Safe for Older Adults to Use Alogliptin and Pioglitazone?

At this time, there have been no observed differences in how well older adults respond to or tolerate this medication compared with younger age groups. However, very few people in clinical studies were older than the age of 75.
At this time, there simply is not enough experience using this medicine in older adults to say for certain that some will not be more sensitive to its effects. Therefore, alogliptin and pioglitazone should probably be used cautiously in older individuals.
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Alogliptin and Pioglitazone Drug Information

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