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Drug Interactions With Alogliptin and Pioglitazone
If you take bile acid sequestrants, insulin, or certain other drugs with alogliptin and pioglitazone, negative interactions may occur. In some cases, these combinations may lower your blood sugar levels too much or decrease the effectiveness of the drugs. To avoid these and other complications, make sure your healthcare provider is aware of all medications, vitamins, and supplements you are taking.
Alogliptin and pioglitazone (Oseni®) can potentially react with a number of products. Some of the drugs that can lead to interactions with alogliptin and pioglitazone include:
- Aripiprazole (Abilify®)
- Axitinib (Inlyta®)
- Bile acid sequestrant cholesterol medications, such as:
- Cholestyramine (Prevalite®, Questran®, Questran® Light)
- Colesevelam (WelChol®)
- Colestipol (Colestid®)
- CYP 2C8 inducers, such as:
- CYP 2C8 inhibitors, such as:
- Celecoxib (Celebrex®)
- Deferasirox (Exjade®)
- Eltrombopag (Promacta®)
- Felodipine (Plendil®)
- Gemfibrozil (Lopid®)
- Irbesartan (Avapro®, Avalide®)
- Lapatinib (Tykerb®)
- Losartan (Cozaar®, Hyzaar®)
- Nilotinib (Tasigna®)
- Quinine (Qualaquin®)
- Rabeprazole (AcipHex®)
- Ritonavir (Norvir®) and lopinavir and ritonavir (Kaletra®)
- Rosiglitazone (Avandia®)
- Sorafenib (Nexavar®)
- Tamoxifen (Nolvadex®)
- Trimethoprim (Primsol® and as sulfamethoxazole/trimethoprim [Bactrim®, Bactrim® DS, Septra®, Septra® DS, Sulfatrim®])
- Insulin of any type
- Insulin secretagogues, such as:
- Meglitinides, such as:
- Nateglinide (Starlix®)
- Repaglinide (Prandin®)
- Sulfonylureas (or sulfonylurea combination medications), such as:
- Chlorpropamide (Diabinese®)
- Glimepiride (Amaryl®)
- Glimepiride and pioglitazone (Duetact®)
- Glimepiride and rosiglitazone (Avandaryl®)
- Glipizide (Glucotrol®, Glucotrol XL®)
- Glipizide and metformin (Metaglip®)
- Glyburide (DiaBeta®, Micronase®, Glynase®)
- Glyburide and metformin (Glucovance®)
- Tolazamide (Tolinase®)
- Tolbutamide (Orinase®)
- Meglitinides, such as:
- Somatropin (Genotropin®, Humatrope®, Norditropin®, Nutropin AQ®, Omnitrope®, Saizen®, Serostim®, Tev-Tropin®, Zorbtive®).
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD