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Drug Interactions With Alogliptin and Pioglitazone

More Detail on Drug Interactions With Alogliptin and Pioglitazone

The following sections explain in detail the potentially negative interactions that can occur when alogliptin and pioglitazone is combined with any of the drugs listed above.
 
Aripiprazole
Alogliptin and pioglitazone may decrease blood levels of aripiprazole, potentially making it less effective. Your healthcare provider may need to adjust your aripiprazole dosage, especially when you first start or stop taking these medications together.
 
Axitinib
Alogliptin and pioglitazone may decrease blood levels of axitinib, potentially making it less effective. Your healthcare provider may choose to monitor your response to axitinib more closely if you take these medications together.
 
Bile Acid Sequestrants
Bile acid sequestrant medicines may decrease the amount of alogliptin and pioglitazone absorbed from the gastrointestinal (GI) tract into the body, which could make the drug less effective. If you are taking both of these drugs, make sure to separate your doses by at least two hours to help minimize the risk for this adverse interaction.
 
CYP 2C8 Inducers
The liver breaks down one of the active ingredients in alogliptin and pioglitazone (pioglitazone [Actos®]) using enzymes known as CYP 2C8 enzymes, and medications known as CYP 2C8 inducers can increase the activity of these enzymes. Thus, combining alogliptin and pioglitazone with one of these drugs may decrease the level of alogliptin and pioglitazone in your bloodstream, possibly making it less effective. Your healthcare provider may need to adjust your alogliptin and pioglitazone dosage if you start or stop taking a CYP 2C8 inducer during treatment.
 
CYP 2C8 Inhibitors
The liver breaks down one of the active ingredients in alogliptin and pioglitazone (pioglitazone [Actos]) using enzymes known as CYP 2C8 enzymes, and medications known as CYP 2C8 inhibitors can decrease the activity of these enzymes. Thus, combining alogliptin and pioglitazone with one of these drugs may increase the level of alogliptin and pioglitazone in your bloodstream, increasing your risk for side effects.
 
It is generally recommended that people who take medicines known to be strong CYP 2C8 inhibitors should not take more than 15 mg of pioglitazone a day. Strong CYP 2C8 inhibitors include gemfibrozil, ritonavir, and sorafenib. People who take other CYP 2C8 inhibitors should be carefully monitored when taking them in combination with alogliptin and pioglitazone.
 
Insulin
Because both insulin and alogliptin and pioglitazone can lower blood sugar, taking these medicines together may increase your risk for dangerously low blood sugar levels (hypoglycemia). Your healthcare provider may need to lower your insulin dosage if you have to combine these drugs.
 
Insulin Secretagogues
Taking insulin secretagogues with alogliptin and pioglitazone could increase your risk for dangerously low blood sugar levels (hypoglycemia). While these medications can be used together to effectively control blood sugar, your healthcare provider may need to monitor you more closely, and possibly adjust your doses, if you take them together. 
 
Somatropin
Somatropin can make alogliptin and pioglitazone less effective. Your healthcare provider may choose to monitor you more closely, and possibly adjust your alogliptin and pioglitazone dose, if you start or stop using somatropin during treatment. 
 
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Alogliptin and Pioglitazone Drug Information

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