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Alogliptin and Pioglitazone Dosage

When treating type 2 diabetes with alogliptin and pioglitazone, the recommended dosage will depend on several factors, such as how well your blood sugar is controlled and other diabetes medications you are taking. The tablets are taken once daily. If you have kidney disease or are taking certain other diabetes medications, you may need a lower dose of this combination medication.

An Introduction to Your Dosage of Alogliptin and Pioglitazone

The dose of alogliptin and pioglitazone (Oseni®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • How well your blood sugar is controlled
  • Other medications you are taking
  • Other medical conditions you may have.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Recommended Alogliptin and Pioglitazone Dosing Guidelines

Your healthcare provider will choose an initial dose of alogliptin and pioglitazone for you based on your individual situation, including other medical conditions you may have and whether you are taking other diabetes medications. This initial amount will then be adjusted based on how well your blood sugar is controlled. Your healthcare provider will check your blood sugar control with regular blood tests, including checks you can do at home and hemoglobin A1C blood tests.
 
The maximum recommended alogliptin and pioglitazone dose for most people is 25 mg/45 mg, which contains 25 mg of alogliptin (Nesina®) and 45 mg of pioglitazone (Actos®). However, people who take certain other medications that interact with alogliptin and pioglitazone will generally be limited to a maximum dose of 25 mg/15 mg (see Drug Interactions With Alogliptin and Pioglitazone).
 
Lower doses are also generally recommended for people with moderate kidney disease. Because people with severe kidney disease should not receive more than 6.25 mg of alogliptin, they should not take alogliptin and pioglitazone, as the lowest available dose contains 12.5 mg. 
 
Diabetes Tips for Seniors

Alogliptin and Pioglitazone Drug Information

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