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What Is Alogliptin and Metformin Used For?

How Does This Medicine Work?

As mentioned already, alogliptin and metformin contains two diabetes medicines that work in different ways to control blood sugar.
Alogliptin belongs to a group of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down certain hormones known as incretin hormones. These hormones cause insulin to be released from the pancreas (which lowers blood glucose levels) in response to meals. They also reduce the amount of glucagon released by the pancreas, which reduces glucose (sugar) production by the liver.
By blocking the DPP-4 enzyme, alogliptin and metformin increases the level of incretin hormones in the blood. This causes more insulin to be made in response to meals, and reduces the amount of glucose made by the liver.
Metformin belongs to a group of medicines known as biguanides. It lowers blood sugar levels in several ways, including by:
  • Decreasing the amount of glucose made by the liver
  • Decreasing the amount of sugar absorbed into the body through the small intestines
  • Improving insulin sensitivity, which helps increase glucose uptake and use by cells.

Can Children Use It?

Alogliptin and metformin has not been adequately studied in children, and is not approved for use in children (usually defined as individuals younger than the age of 18). Talk to your child's healthcare provider about the risks and benefits of using this medication in children.

Is It Safe for Older Adults to Use Alogliptin and Metformin?

Yes -- older adults can use this medication. However, older adults are more likely to have reduced kidney function, which may put them at a higher risk for alogliptin and metformin side effects. If you are 80 years old or older, your healthcare provider should check your kidney function before starting treatment. People with kidney disease should not be treated with this medication.
Healthy Eating for People With Diabetes

Alogliptin and Metformin Information

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