Endocrine System Channel
Topics
Medications
Quicklinks
Related Channels
Drug Interactions With Alogliptin and Metformin
If certain decongestants, thyroid medications, calcium channel blockers, or other products are combined with alogliptin and metformin, drug interactions may occur that could decrease the effectiveness of both medications and/or increase your risk of side effects. To prevent these problems, your healthcare provider may adjust your dosages or monitor you more closely.
Alogliptin and metformin (Kazano®) can potentially react with several different products. Some of the drugs that can lead to interactions with alogliptin and metformin include:
- Calcium channel blockers, such as:
- Amlodipine (Norvasc®)
- Diltiazem (Cardizem®, Cardizem CD®, Cardizem LA®, Cartia XT®, Dilacor XR®, Dilt-CD®, Diltia XT®, Dilt-XR®, Taztia XT®, Tiazac®)
- Felodipine (Plendil®)
- Isradipine (Dynacirc®, Dynacirc CR®)
- Nisoldipine (Sular®)
- Nicardipine (Cardene®, Cardene SR®)
- Nifedipine (Adalat CC®, Afeditab CR®, Nifediac CC®, Nifedical XL®, Procardia®, Procardia XL®)
- Nimodipine (Nimotop®)
- Verapamil (Calan®, Calan SR®, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®)
- Certain carbonic anhydrase inhibitors, such as:
- Acetazolamide (Diamox®, Diamox® Sequels®)
- Dichlorphenamide (Daranide®)
- Methazolamide
- Topiramate (Topamax®)
- Zonisamide (Zonegran®)
- Certain decongestants, such as phenylephrine and pseudoephedrine (Sudafed®)
- Cimetidine (Tagamet®) and Ranitidine (Zantac®)
- Corticosteroids, such as:
- Beclomethasone inhaler (Qvar®)
- Betamethasone (Celestone®)
- Budesonide inhalation (Pulmicort®)
- Cortisone
- Dexamethasone (Decadron®)
- Fludrocortisone (Florinef®)
- Fluticasone inhaler (Flovent®)
- Hydrocortisone (Cortef®)
- Methylprednisolone (Depo-Medrol®, Medrol®)
- Mometasone inhaler (Asmanex®)
- Prednisolone (Orapred®, Pediapred®)
- Prednisone
- Triamcinolone (Azmacort®, Kenalog®, Aristospan®)
- Digoxin (Lanoxin®)
- Diuretics, such as:
- Amiloride (Midamor®) or amiloride-HCTZ (Moduretic®)
- Bumetanide (Bumex®)
- Chlorothiazide (Diuril®)
- Chlorthalidone (Thalitone®)
- Ethacrynic acid (Edecrin®)
- Furosemide (Lasix®)
- Hydrochlorothiazide (Esidrix®, HydroDIURIL®, Microzide®, Oretic®)
- Metolazone (Zaroxolyn®)
- Spironolactone (Aldactone®) or spironolactone-HCTZ (Aldactazide®)
- Torsemide (Demadex®)
- Triamterene (Dyrenium®) or triamterene/HCTZ (Dyazide®, Maxzide®)
- Estrogens
- Insulin of any type
- Insulin secretogogues, such as:
- Meglitinides, such as:
- Nateglinide (Starlix®)
- Repaglinide (Prandin®)
- Sulfonylureas (or sulfonylurea combination medications), such as:
- Chlorpropamide (Diabinese®)
- Glimepiride (Amaryl®)
- Glimepiride and pioglitazone (Duetact®)
- Glimepiride and rosiglitazone (Avandaryl®)
- Glipizide (Glucotrol®, Glucotrol XL®)
- Glipizide and metformin (Metaglip®)
- Glyburide (DiaBeta®, Micronase®, Glynase®)
- Glyburide and metformin (Glucovance®)
- Tolazamide (Tolinase®)
- Tolbutamide (Orinase®)
- Meglitinides, such as:
- Isoniazid
- Morphine
- Niacin ("nicotinic acid"; brand names include Niacor®, Niaspan®, Slo-Niacin®, and several others)
- Oral contraceptives (birth control pills)
- Phenothiazine medications, such as:
- Chlorpromazine (Thorazine®)
- Fluphenazine (Prolixin®)
- Perphenazine (Trilafon®)
- Prochlorperazine (Compazine®, Compro®)
- Thioridazine (Mellaril®)
- Trifluoperazine (Stelazine®)
- Phenytoin (Dilantin®)
- Procainamide
- Quinidine
- Quinine (Qualaquin®)
- Somatropin (Genotropin®, Humatrope®, Norditropin®, Nutropin AQ®, Omnitrope®, Saizen®, Serostim®, Tev-Tropin®, Zorbtive®)
- Thyroid medications, such as:
- Liothyronine (Cytomel®)
- Liotrix (Thyrolar®)
- Levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Tirosint®, Unithroid®)
- Thyroid (Armor® Thyroid, Nature-Throid®, Westhroid®)
- Trimethoprim (Primsol® and as sulfamethoxazole/trimethoprim [Bactrim®, Bactrim® DS, Septra®, Septra® DS, Sulfatrim®])
- Vancomycin (Vancocin®).
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD