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Drug Interactions With Alogliptin and Metformin

More Detail on Drug Interactions With Alogliptin and Metformin

The following sections explain in detail the potentially negative interactions that can occur when alogliptin and metformin is combined with any of the drugs listed above.
 
Calcium Channel Blockers
Because calcium channel blockers can increase blood glucose (sugar) levels, taking them with alogliptin and metformin could make alogliptin and metformin less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your alogliptin and metformin dosage if you start or stop taking a calcium channel blocker. 
 
Carbonic Anhydrase Inhibitors
Taking alogliptin and metformin with certain medications known as carbonic anhydrase inhibitors could increase your risk for a potentially serious problem known as lactic acidosis (a buildup of acid in the blood). These medications can be used together, but should be done so with caution.
 
Certain Decongestants
Because certain decongestants can cause high blood glucose levels (hyperglycemia), taking them with alogliptin and metformin could make alogliptin and metformin less effective. Decongestants are in many cough and cold products, so make sure to talk to your healthcare provider before taking any cough or cold medication.
 
Cimetidine and Ranitidine
Taking alogliptin and metformin with cimetidine or ranitidine could increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Talk to your healthcare provider about this potential interaction before taking these drugs together.
 
Corticosteroids
Corticosteroids have the potential to cause high blood glucose levels (hyperglycemia). Taking them with alogliptin and metformin could make alogliptin and metformin less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your alogliptin and metformin dose if you start or stop taking a corticosteroid. 
 
Digoxin
Taking alogliptin and metformin with digoxin could increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely in this case, especially if you start or stop taking digoxin.
 
Diuretics
Because diuretics may increase blood glucose (sugar) levels, taking them with alogliptin and metformin could make alogliptin and metformin less effective. You may need to be monitored more closely in this case, and your healthcare provider may need to adjust your alogliptin and metformin dose if you start or stop taking a diuretic medication.
 
Estrogens
Taking alogliptin and metformin with estrogens could make alogliptin and metformin less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely in this case, and your healthcare provider may need to adjust your alogliptin and metformin dose, especially when starting or stopping an estrogen.
 
Insulin
Because both insulin and alogliptin and metformin can lower blood sugar, taking these medicines together may increase your risk for dangerously low blood sugar levels (hypoglycemia). This doesn't mean these medicines cannot be used together. However, your healthcare provider may need to lower your insulin dose if you take alogliptin and metformin.
 
Insulin Secretogogues
Because insulin secretogogues and alogliptin and metformin can both lower blood sugar levels, taking these medicines together may increase your risk for dangerously low blood sugar levels (hypoglycemia). This doesn't mean these medicines cannot be used together. However, your healthcare provider may need to lower your insulin secretogogue dose if you take it with alogliptin and metformin.
 
Isoniazid
Because isoniazid may cause high blood glucose levels (hyperglycemia), taking it with alogliptin and metformin could make alogliptin and metformin less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your alogliptin and metformin dose if you start or stop taking isoniazid.  
 
Morphine
Taking alogliptin and metformin with morphine could increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you start or stop taking morphine during alogliptin and metformin treatment. 
 
Niacin
Taking alogliptin and metformin with niacin can make alogliptin and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely in this case, and your healthcare provider may need to adjust your alogliptin and metformin dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Taking alogliptin and metformin with oral contraceptives (birth control pills) could make alogliptin and metformin less effective, potentially increasing your risk of high blood sugar (hyperglycemia). You may need to be monitored more closely in this case, and your healthcare provider may need to adjust your alogliptin and metformin dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Phenothiazine medications may cause high blood sugar (hyperglycemia) and could, therefore, make alogliptin and metformin less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your alogliptin and metformin dose, especially if you start or stop taking a phenothiazine.  
 
Phenytoin
Phenytoin may cause high blood sugar (hyperglycemia) and could, therefore, make alogliptin and metformin less effective. You may need to be monitored more closely in this case, and your healthcare provider may need to adjust your alogliptin and metformin dose, especially if you start or stop taking phenytoin.  
 
Procainamide
Taking alogliptin and metformin with procainamide could increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely in this case, especially if you start or stop taking procainamide.
 
Quinidine
Quinidine could increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely, especially if you start or stop taking quinidine during alogliptin and metformin treatment.
 
Quinine
Quinine may increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely, especially if you start or stop taking quinine during alogliptin and metformin treatment.
 
Somatropin
Taking somatropin with alogliptin and metformin can make alogliptin and metformin less effective, increasing your risk for high blood sugar (hyperglycemia). Your healthcare provider may need to adjust your alogliptin and metformin dose, especially if you start or stop using somatropin. 
 
Thyroid Medications
Taking alogliptin and metformin with thyroid medications can make alogliptin and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely in this case, and your healthcare provider may need to adjust your alogliptin and metformin dose, especially when starting or stopping a thyroid medication.
 
Trimethoprim
Taking trimethoprim with alogliptin and metformin could increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely, especially when starting or stopping trimethoprim during alogliptin and metformin treatment.
 
Vancomycin
Taking vancomycin with alogliptin and metformin could increase the level of alogliptin and metformin in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely in this case, especially when starting or stopping vancomycin.
 
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