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Actoplus Met XR Side Effects

Although most people have no problems with Actoplus Met XR and find it an effective type 2 diabetes medication, adverse reactions are possible. Possible Actoplus Met XR side effects include signs of the common cold, nausea, and urinary tract infections. Potentially serious problems that require medical care include low blood sugar, trouble breathing, and chest pain.

An Introduction to Side Effects of Actoplus Met XR

As with any medicine, side effects are possible with Actoplus Met® XR (pioglitazone and metformin XR). However, not everyone who takes the drug will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Actoplus Met XR. Your healthcare provider can discuss a more complete list with you.)

Common Actoplus Met XR Side Effects

The side effect data from the prescribing information ("package insert") for Actoplus Met XR was taken from clinical trials in which a combination of pioglitazone and immediate-release metformin was used. Since Actoplus Met XR contains pioglitazone plus extended-release metformin, it is possible that the exact percentages might differ. Nonetheless, this data provides a general picture of the side effects that can be expected with Actoplus Met XR.
Based on these studies, the most common side effects of pioglitazone plus immediate-release metformin included:
  • Upper respiratory tract infections (similar to the common cold or flu) -- in up to 13.5 percent of people
  • Swelling or fluid retention (edema) of the lower leg or ankles -- up to 11.3 percent
  • Weight gain -- up to 6.7 percent (see Actoplus Met XR and Weight Gain)
  • Diarrhea -- up to 5.8 percent
  • Nausea -- up to 5.8 percent
  • Urinary tract infections (UTIs), including bladder infections -- up to 5.8 percent
  • Dizziness -- up to 5.4 percent
  • Headache -- up to 5.3 percent
  • Sinus infection or irritation -- up to 5 percent.
Type 2 Diabetes: Fact or Fiction

Actoplus Met XR Medication Information

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