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Actoplus Met XR Drug Interactions

Isoniazid
Taking Actoplus Met XR with isoniazid can make Actoplus Met XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met XR dose, especially when starting or stopping isoniazid.
 
Niacin
If Actoplus Met XR and niacin are taken together, this makes Actoplus Met XR less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met XR dose, especially when starting or stopping niacin.
 
Oral Contraceptives
If Actoplus Met XR and oral contraceptives (birth control pills) are combined, this can make Actoplus Met XR less effective, increasing your chance of high blood sugar (hyperglycemia). To prevent this drug interaction, you may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met XR dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Taking Actoplus Met XR with phenothiazines can make Actoplus Met XR less effective, possibly increasing your chance of high blood sugar (hyperglycemia). As a result, you may need to be monitored more closely, and your healthcare provider may need to adjust your Actoplus Met XR dose, especially when starting or stopping a phenothiazine.
 
Rifampin or Rifapentine
Taking Actoplus Met XR and rifampin or rifapentine together can decrease the level of Actoplus Met XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of Actoplus Met XR to prevent this drug interaction from occurring.
 
Ritonavir
If Actoplus Met XR and ritonavir are taken together, this can increase the level of Actoplus Met XR in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of Actoplus Met XR to prevent this interaction.
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Actoplus Met XR Medication Information

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