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Actoplus Met XR and Weight Gain

Clinical studies have shown that Actoplus Met XR (pioglitazone and metformin XR) can cause weight gain. If the increase in weight is rapid, you should definitely contact your healthcare provider, as this may be a sign of a serious heart condition. If the increase is gradual, lifestyle changes alone may be enough to combat this; however, it should still be reported to your healthcare provider.

Does Actoplus Met XR Cause Weight Gain?

Weight gain is a possible side effect of Actoplus Met® XR (pioglitazone and metformin XR). Sometimes this gain is minor, but sometimes it can signal a more serious problem. Rapid weight gain (more than three to five pounds in a week) could be a sign of congestive heart failure, which is a less common but very serious side effect of Actoplus Met XR.

Statistics on Weight Gain With Actoplus Met XR

In clinical studies, up to 6.7 percent of people taking a combination of pioglitazone and metformin (the two active ingredients in Actoplus Met XR) gained weight, although the amount was usually small (about four pounds on average).
This is likely due to the pioglitazone component, since pioglitazone has been shown to cause weight gain, and metformin may actually cause weight loss (see Metformin and Weight Loss).
The study also suggested that the higher the dosage, the greater the chance of weight gain.

What About Rapid Weight Gain?

When considering weight gain and Actoplus Met XR, remember that this medicine may make congestive heart failure worse or, in some cases, even cause it. One of the main symptoms of heart failure is unexplained weight gain. In fact, people with symptoms of congestive heart failure can often have rapid weight gain (three to five pounds) over several days.
This weight gain is often combined with other symptoms, such as a cough and/or swelling in the ankles, feet, or legs. Make sure to contact your healthcare provider if you notice unexplained weight gain or swelling while taking Actoplus Met XR.
(Click Symptoms of Congestive Heart Failure for more information.)
Healthy Eating for People With Diabetes

Actoplus Met XR Medication Information

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